Most people are aware of the dangers of antibiotics, even those who advocate them. Most vets and pet owners have learned that these medications create antibiotic resistance and destroy the healthy flora in the gut.
About 10 years ago, microbiologist Thad Stanton led a USDA study. He discovered that not only does antibiotic use in pigs change the bacterial flora in the gut, but even low doses of the drug given for only two weeks also caused a drastic increase in the number of E-coli bacteria in the gut … the opposite effect they had expected. And those bacteria showed a large jump in resistance to antibiotics.
Antibiotic resistance in dogs is something you need to know about … so here’s some background on this troubling phenomenon that affects humans and animals alike.
The Discovery Of Antibiotic Resistance
The warning bells about antibiotic resistance first rang in the 1970s when the late microbiologist Stuart Levy published studies about how the use of antibiotics in chicken feed led to antibiotic-resistant bacteria that could actually be spread to the microbiome of farmers and beyond.
This information raised the ire of those in animal production and pharmaceutical companies and so further studies were limited. Levy believed “… industry didn’t want more studies. They were upset that our data showed them to be wrong. This was highly political.”
What Are Antibiotics?
In the 1920s Sir Alexander Fleming accidentally discovered penicillin which was to be the first mass-produced antibiotic. During World War II. penicillin was used to treat wounds with risk of bacterial infection that could lead to death. It saved tens of thousands of lives.
In the decades since, antibiotics have become powerful, lifesaving medicines used to treat illnesses and infections caused by specific bacteria in humans and animals … including your dog. They kill bacteria … but not viruses or fungus. They’re most often used to treat urinary, respiratory and digestive infections and specific symptoms like diarrhea, ear and sinus issues. And they’ve become very commonplace in their use.
But as we learn more about the immune system and the microbiome, it’s becoming equally well-known that antibiotics don’t just kill the bacteria that cause infection. Antibiotics kill ALL bacteria … even beneficial bacteria in the gut that aid in digestion, produce vitamins, help in hormone production and destroy harmful bacteria. Without these friendly bacteria, your dog can contract a long-term illness or develop chronic disease that’s hard to treat.
What Are Antibiotic-Resistant Bacteria?
Antibiotic resistance happens when bacteria don’t respond to the antibiotics designed to kill them. This creates a superbug so stronger antibiotics are produced. And even then, they don’t work on these new strains of bacteria. So bacteria are not killed and these types of bacterial infections in dogs continue to spread. It’s the bacteria that resist the antibiotics, not the body.
In 2013, the Centers For Disease Control (CDC) published a paper on the seriousness of antibiotic resistance threats. They call antibiotic resistance “one of the biggest public health challenges of our time […] Fighting this threat is a public health priority that requires a collaborative global approach across sectors.”
Antibiotic resistance is a natural phenomenon. Bacteria naturally find new ways to avoid the effects of the antibiotics used for the infections they cause.
According to Dr Richard S Patton PhD, antibiotic-resistant bacteria are doing what any species is designed to do. “The two irreducible pillars of existence for any species are first, survival and second, reproduction.” (6) And just as mammals adapt to shortages of water and food with digestive tracts and enzymes needed to consume and survive on the food sources available, bacteria also engage in survivor mode and become resistant to antibiotics.
This concept was echoed by the CDC in 2013: “Because antibiotic resistance occurs as part of a natural evolution process, it can be significantly slowed but not stopped. Therefore, new antibiotics will always be needed to keep up with resistant bacteria.”
As early as 1945, Fleming issued a warning about antibiotic overuse with these words: “… the public will demand [the drug and] … then will begin an era … of abuses.”
The world has known about antibiotic resistance for almost 50 years and yet today, they are still prescribed with little hesitation. The World Health Organization (WHO) and the CDC lead the way with warnings about limiting the use of antibiotics and are the first to admit their abuse.
Causes Of Antibiotic Resistance
What started as a lifesaving solution to infection, soon became a source of a bigger problem. Here are causes of antibiotic resistance:
- Over-prescribing of antibiotics
- Prescribing antibiotics unnecessarily or without proper bacteria testing
- Prescribing antibiotics beyond the scope of what is needed
- Patients who fail to finish an entire course of antibiotics so remaining bacteria can become a “superbug” and resist future antibiotics
- Overuse of antibiotics in livestock and fish farming operations
- Poor infection control in hospitals and health care facilities
- Poor hygiene and sanitation
- Failure to develop new antibiotics
In 2020, the WHO declared antimicrobial (formerly antibiotic) resistance “one of the top 10 global public health threats facing humanity.” It cited misuse and overuse of antibiotics as the source of drug-resistant pathogens.
“The world urgently needs to change the way it prescribes and uses antibiotics. Even if new medicines are developed, without behavior change, antibiotic resistance will remain a major threat…. Where antibiotics can be bought for human or animal use without a prescription, the emergence and spread of resistance are made worse.”
A 2015 report, The Antibiotic Resistance Crisis, states: “The antibiotic resistance crisis has been attributed to the overuse and misuse of these medications, as well as a lack of new drug development by the pharmaceutical industry due to reduced economic incentives and challenging regulatory requirements.” According to the report and data from the CDC and FDA, new antibiotics approved for use have steadily decreased since 1985 while approval for cancer drugs has risen.
In 2017, the cost of developing an antibiotic was about $1.5 billion but the return on investment was only $46 million. In contrast, the low cost of antibiotics generally priced at $1,000 to $3,000 for a course is considerably less than chemotherapy that can cost tens of thousands of dollars. A drug used to treat a neuromuscular disease could be valued as high as $1 billion. Also, when infectious disease specialists and institutions like the CDC and WHO advise minimizing the use of antibiotics, the monetary incentive to develop new drugs is even less.
How Antibiotic Resistance Spreads To Humans
This has brought into question the spread of antibiotic resistance between companion animals and humans. In this 2020 study, researchers looked at 303 dogs and cats for a year in three European countries. They reported studies confirming there was already high use of broad-spectrum antimicrobials that were often not in line with current European guidelines. They found that while antibiotic use in pets was lower than in farming operations, there was a high use of “critically important antimicrobials” … meaning stronger antibiotics.
They concluded antibiotic use “does not lie so much within the quantity but rather within the quality of antimicrobials used. Especially from a One-Health perspective, companion animals might be a source of transmission of resistance genes and/or resistant bacteria to humans. At the country level, higher resistance in companion animals seems to follow trends of higher antimicrobial use.”